作者
Allaura S Cone, Xuegang Yuan, Li Sun, Leanne C Duke, Michael P Vreones, Allison N Carrier, Stephanie M Kenyon, Spencer R Carver, Sarah D Benthem, Alina C Stimmell, Shawn C Moseley, David Hike, Samuel C Grant, Aaron A Wilber, James M Olcese, David G Meckes Jr
发表日期
2021
期刊
Theranostics
卷号
11
期号
17
页码范围
8129
出版商
Ivyspring International Publisher
简介
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that affects more than 44 million people worldwide. Despite the high disease burden, there is no effective treatment for people suffering from AD. Mesenchymal stem cells (MSCs) are multipotent stromal cells that have been widely studied due to their therapeutic potential. However, administration of cells has been found to have a multitude of limitations. Recently, extracellular vesicles (EVs) derived from MSCs have been studied as a therapeutic candidate, as they exhibit similar immunoprotective and immunomodulatory abilities as the host human MSCs.
Methods: To test the potential therapeutic effects of MSC EVs, human bone-marrow derived MSCs were grown in three-dimensional (3D) cell culture, and small EVs were harvested using differential ultracentrifugation. These small EVs were given to non-transgenic (NT) or 5XFAD (5 familial …
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AS Cone, X Yuan, L Sun, LC Duke, MP Vreones… - Theranostics, 2021