作者
Massimo Lazzeri, Alexander Haese, Alberto Abrate, Alexandre de la Taille, Joan Palou Redorta, Thomas McNicholas, Giovanni Lughezzani, Giuliana Lista, Alessandro Larcher, Vittorio Bini, Andrea Cestari, Nicolòmaria Buffi, Markus Graefen, Olivier Bosset, Philippe Le Corvoisier, Alberto Breda, Pablo de la Torre, Linda Fowler, Jacques Roux, Giorgio Guazzoni
发表日期
2013/8
期刊
BJU international
卷号
112
期号
3
页码范围
313-321
简介
Objectives
- To test the sensitivity, specificity and accuracy of serum prostate‐specific antigen isoform [‐2]proPSA (p2PSA), %p2PSA and the prostate health index (PHI), in men with a family history of prostate cancer (PCa) undergoing prostate biopsy for suspected PCa.
- To evaluate the potential reduction in unnecessary biopsies and the characteristics of potentially missed cases of PCa that would result from using serum p2PSA, %p2PSA and PHI.
Patients and Methods
- The analysis consisted of a nested case–control study from the PRO‐PSA Multicentric European Study, the PROMEtheuS project.
- All patients had a first‐degree relative (father, brother, son) with PCa.
- Multivariable logistic regression models were complemented by predictive accuracy analysis and decision‐curve analysis.
Results
- Of the 1026 patients included in the PROMEtheuS cohort, 158 (15.4%) had a first‐degree relative with PCa. p2PSA …
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M Lazzeri, A Haese, A Abrate, A de la Taille… - BJU international, 2013