作者
Nicola Fossati, Nicolò Maria Buffi, Alexander Haese, Carsten Stephan, Alessandro Larcher, Thomas McNicholas, Alexandre de la Taille, Massimo Freschi, Giovanni Lughezzani, Alberto Abrate, Vittorio Bini, Joan Palou Redorta, Markus Graefen, Giorgio Guazzoni, Massimo Lazzeri
发表日期
2015/7/1
期刊
European urology
卷号
68
期号
1
页码范围
132-138
出版商
Elsevier
简介
Background
Currently available predictive models fail to assist clinical decision making in prostate cancer (PCa) patients who are potential candidates for radical prostatectomy (RP). New biomarkers would be welcome.
Objective
To test the hypothesis that prostate-specific antigen (PSA) isoform p2PSA and its derivatives, percentage of p2PSA to free PSA (%p2PSA) and the Prostate Health Index (PHI), predict PCa characteristics at final pathology.
Design, setting, and participants
An observational prospective multicentre European study was performed in 489 consecutive PCa patients treated with RP. Total PSA (tPSA), free PSA (fPSA), and p2PSA levels were determined. The %fPSA [(fPSA / tPSA) × 100], %p2PSA [(p2PSA pg/ml) / (fPSA ng/ml × 1000) × 100], and PHI [(p2PSA / fPSA) × √tPSA] were calculated.
Intervention
Open or robot-assisted RP.
Outcome measurements and statistical analysis
Logistic regression …
学术搜索中的文章
N Fossati, NM Buffi, A Haese, C Stephan, A Larcher… - European urology, 2015