作者
Frank C Brosius III, Charles E Alpers, Erwin P Bottinger, Matthew D Breyer, Thomas M Coffman, Susan B Gurley, Raymond C Harris, Masao Kakoki, Matthias Kretzler, Edward H Leiter, Moshe Levi, Richard A McIndoe, Kumar Sharma, Oliver Smithies, Katalin Susztak, Nobuyuki Takahashi, Takamune Takahashi, Animal Models of Diabetic Complications Consortium
发表日期
2009/12/1
来源
Journal of the American Society of Nephrology
卷号
20
期号
12
页码范围
2503-2512
出版商
LWW
简介
Diabetic nephropathy is a major cause of ESRD worldwide. Despite its prevalence, a lack of reliable animal models that mimic human disease has delayed the identification of specific factors that cause or predict diabetic nephropathy. The Animal Models of Diabetic Complications Consortium (AMDCC) was created in 2001 by the National Institutes of Health to develop and characterize models of diabetic nephropathy and other complications. This interim report and our online supplement detail the progress made toward that goal, specifically in the development and testing of murine models. Updates are provided on validation criteria for early and advanced diabetic nephropathy, phenotyping methods, the effect of background strain on nephropathy, current best models of diabetic nephropathy, negative models, and views of future directions. AMDCC investigators and other investigators in the field have yet to …
引用总数
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FC Brosius III, CE Alpers, EP Bottinger, MD Breyer… - Journal of the American Society of Nephrology, 2009