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The performance of deep learning models generally relies on large and high-quality labeled datasets. However, in medical domain, as labeling process is much more laborious and time-consuming, most medical datasets are much smaller compared with natural image datasets. To mitigate this weakness, recent researches in medical image analysis adopt semi-supervised learning methods, especially consistency regularization methods to learn from a large amount of unlabeled medical data. However, as these semi-supervised learning methods are originally designed for tasks of natural images, specific properties of medical domain are not fully investigated and utilized. In this paper, we present DK-Consistency, a domain knowledge guided consistency regularization method for semi-supervised breast cancer diagnosis in ultrasound images. In DK-Consistency, domain knowledge of medical doctors is first …