作者
Bruno Millet, Nematollah Jaafari, Mircea Polosan, Nicolas Baup, Bruno Giordana, Claire Haegelen, Stephan Chabardès, Denys Fontaine, Bertrand Devaux, Jérome Yelnik, Philippe Fossati, Bruno Aouizerate, Marie Odile Krebs, Gabriel Robert, Thérèse Jay, Philippe Cornu, Marc Vérin, Sophie Drapier, Dominique Drapier, Paul Sauleau, Julie Péron, Florence Le Jeune, Florian Naudet, Jean Michel Reymann
发表日期
2014/8/1
期刊
European Neuropsychopharmacology
卷号
24
期号
8
页码范围
1229-1239
出版商
Elsevier
简介
High-frequency deep brain stimulation (DBS) represents a major stake for treatment for treatment-resistant depression (TRD). We describe a preliminary trial of DBS of two potential brain targets in chronic TRD: the nucleus accumbens (Acb) and, in the event of failure, the caudate nucleus. Patients were followed for 6 months before surgery (M0). From M1 to M5, they underwent stimulation of the Acb target. PET scans allowed us to track metabolic modifications resulting from this stimulation. The caudate target of nonresponders was stimulated between M5 and M9. Patients then entered an extension phase, in which it was possible to adapt stimulation parameters and treatments. Six patients were included and four were operated on. At M5, none of the patients were either responders or remitters, but we did observe a decrease in Hamilton Depression Rating Scale (HDRS) scores. Three patients were switched to …
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B Millet, N Jaafari, M Polosan, N Baup, B Giordana… - European Neuropsychopharmacology, 2014