作者
Brittany N Dugger, Charles H Adler, Holly A Shill, John Caviness, Sandra Jacobson, Erika Driver-Dunckley, Thomas G Beach, Arizona Parkinson's Disease Consortium
发表日期
2014/5/1
期刊
Parkinsonism & related disorders
卷号
20
期号
5
页码范围
525-529
出版商
Elsevier
简介
Introduction
Many clinicopathological studies do not specify the presence of other pathologies located within the brain, so disease heterogeneity may be under appreciated.
Objective
The purpose of this study was to determine the frequencies of concomitant pathologies among parkinsonian disorders.
Methods
Data from the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND), an ongoing longitudinal clinical-neuropathological study, was used to analyze concomitant pathologies, including Alzheimer's disease (AD), argyrophilic grains (Arg), cerebral amyloid angiopathy (CAA), cerebral white matter rarefaction (CWMR) and overlap of each parkinsonian disorder in clinico-pathologically defined Parkinson's disease (PD; N = 140), dementia with Lewy bodies (DLB; N = 90), progressive supranuclear palsy (PSP; N = 64), multiple system atrophy (MSA; N = 6), corticobasal degeneration (CBD; N = 7); and …
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