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Recently, literature recognized an association between coronavirus disease-19 (COVID-19) and coagulopathy [1]. COVID-19 illness severity is positively correlated with coagulopathy markers, including prolonged prothrombin time, increased fibrin degradation products, decreased platelet count, and elevated D-dimer [2–8]. However, the pathogenesis of COVID-19-induced coagulation and the role of anticoagulation treatment remain unclear. Presence of intravascular and extravascular fibrin is a prominent feature of sepsis-induced acute lung injury [9]. COVID-19 is identified as a sepsis-inducing pathogen, which may contribute to low PaO2 levels associated with decreased arterial blood perfusion secondary to sepsis and coagulopathy [10]. An observational study reported that many critically ill COVID-19 patients presented with clinical manifestations of shock, indicating vascular endothelial dysregulation [10 …