作者
Seithikurippu R Pandi-Perumal, Ahmed S BaHammam, Gregory M Brown, D Warren Spence, Vijay K Bharti, Charanjit Kaur, Rüdiger Hardeland, Daniel P Cardinali
发表日期
2013/4
来源
Neurotoxicity research
卷号
23
页码范围
267-300
出版商
Springer-Verlag
简介
The pineal product melatonin has remarkable antioxidant properties. It is secreted during darkness and plays a key role in various physiological responses including regulation of circadian rhythms, sleep homeostasis, retinal neuromodulation, and vasomotor responses. It scavenges hydroxyl, carbonate, and various organic radicals as well as a number of reactive nitrogen species. Melatonin also enhances the antioxidant potential of the cell by stimulating the synthesis of antioxidant enzymes including superoxide dismutase, glutathione peroxidase, and glutathione reductase, and by augmenting glutathione levels. Melatonin preserves mitochondrial homeostasis, reduces free radical generation and protects mitochondrial ATP synthesis by stimulating Complexes I and IV activities. The decline in melatonin production in aged individuals has been suggested as one of the primary contributing factors for the …
学术搜索中的文章
SR Pandi-Perumal, AS BaHammam, GM Brown… - Neurotoxicity research, 2013