作者
Chu Chu, Tuo Li, Hans Albert Pedersen, Kenneth T Kongstad, Jizhong Yan, Dan Staerk
发表日期
2019/6/1
期刊
Phytochemistry Letters
卷号
31
页码范围
47-52
出版商
Elsevier
简介
Type 2 diabetes is a chronic metabolic disorder affecting millions of people worldwide, and new drug leads are urgently needed. The dried stem of Dendrobium officinale is used in China to alleviate the symptoms of diabetes, but investigations of its bioactive components have been limited. We have applied a simple, fast, and effective method, combining triple high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibition with high-performance liquid chromatography - photodiode-array detection - high-resolution mass spectrometry - solid-phase extraction - nuclear magnetic resonance spectroscopy (HR-bioassay/HPLC-PDA-HRMS-SPE-NMR). Two new compounds, 3,4,4′-trihydroxy-5-methoxybibenzyl (5) and 3,4-dihydroxy-3′,4′,5-trimethoxybibenzyl (8a), along with fourteen known compounds, were identified. Twelve of these were associated with radical scavenging activity, six …
学术搜索中的文章
C Chu, T Li, HA Pedersen, KT Kongstad, J Yan… - Phytochemistry Letters, 2019