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Systems for untethered sensing and recording of activity of one or more electrically excitable cells in a target region includes at least one untethered probe. Each untethered probe includes at least one signal detector, configured to electrically couple to the target region, measure the activity of the one or more electrically excitable cells, and produce an electrical signal in response to the activity of the one or more electrically excitable cells, and at least one light source, electrically coupled to the at least one signal detector, to receive the electrical signal and emit a light signal representing the activity of the one or more electrically excitable cells. Methods for untethered sensing and recording of activity of one or more electrically excitable cells in a target region are also provided.