作者
Lisa M Askie, Brian A Darlow, Neil Finer, Barbara Schmidt, Ben Stenson, William Tarnow-Mordi, Peter G Davis, Waldemar A Carlo, Peter Brocklehurst, Lucy C Davies, Abhik Das, Wade Rich, Marie G Gantz, Robin S Roberts, Robin K Whyte, Lorrie Costantini, Christian Poets, Elizabeth Asztalos, Malcolm Battin, Henry L Halliday, Neil Marlow, Win Tin, Andrew King, Edmund Juszczak, Colin J Morley, Lex W Doyle, Val Gebski, Kylie E Hunter, Robert J Simes
发表日期
2018/6/5
期刊
Jama
卷号
319
期号
21
页码范围
2190-2201
出版商
American Medical Association
简介
Importance
There are potential benefits and harms of hyperoxemia and hypoxemia for extremely preterm infants receiving more vs less supplemental oxygen.
Objective
To compare the effects of different target ranges for oxygen saturation as measured by pulse oximetry (Spo2) on death or major morbidity.
Design, Setting, and Participants
Prospectively planned meta-analysis of individual participant data from 5 randomized clinical trials (conducted from 2005-2014) enrolling infants born before 28 weeks’ gestation.
Exposures
Spo2target range that was lower (85%-89%) vs higher (91%-95%).
Main Outcomes and Measures
The primary outcome was a composite of death or major disability (bilateral blindness, deafness, cerebral palsy diagnosed as ≥2 level on the Gross Motor Function Classification System, or Bayley-III cognitive or language score <85) at a corrected age of 18 to 24 months. There were 16 secondary …
学术搜索中的文章
LM Askie, BA Darlow, N Finer, B Schmidt, B Stenson… - Jama, 2018