作者
Huanliang Liu, Mary Carrington, Chunhui Wang, Sarah Holte, Jean Lee, Benjamin Greene, Florian Hladik, David M Koelle, Anna Wald, Kyoko Kurosawa, Charles R Rinaldo, Connie Celum, Roger Detels, Lawrence Corey, M Juliana McElrath, Tuofu Zhu
发表日期
2006/3/1
期刊
The Journal of infectious diseases
卷号
193
期号
5
页码范围
698-702
出版商
The University of Chicago Press
简介
In 1716 individuals—801 human immunodeficiency virus (HIV)–1–seropositive individuals, 217 high-risk HIV-1–seronegative individuals, and 698 general HIV-1–seronegative individuals—from a Seattle cohort and a Multicenter AIDS Cohort Study cohort, the association between HIV-1 susceptibility and repeat-region polymorphisms in the gene for the dendritic cell–specific intercellular adhesion molecule-3–grabbing nonintegrin–related molecule (DC-SIGNR) was investigated; 16 genotypes were found in the DC-SIGNR repeat region. The DC-SIGNR homozygous 7/7 repeat was found to be associated with an increased risk of HIV-1 infection (17.5% in high-risk HIV-1–seronegative individuals vs. 28.5% in HIV-1–seropositive individuals; P=.0015), whereas the DC-SIGNR heterozygous 7/5 repeat tended to be correlated with resistance to HIV-1 infection (35.5% in high-risk HIV-1–seronegative individuals vs …
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H Liu, M Carrington, C Wang, S Holte, J Lee, B Greene… - The Journal of infectious diseases, 2006