作者
Caroline M Mitchell, Leslie McLemore, Katharine Westerberg, Rena Astronomo, Kimberly Smythe, Carolyn Gardella, Matthias Mack, Amalia Magaret, Dorothy Patton, Kathy Agnew, M Juliana McElrath, Florian Hladik, David Eschenbach
发表日期
2014/8/15
期刊
The Journal of infectious diseases
卷号
210
期号
4
页码范围
651-655
出版商
Oxford University Press
简介
Background. Depot medroxyprogesterone acetate (DMPA) has been linked to human immunodeficiency virus type 1 (HIV-1) acquisition.
Methods. Vaginal microbiota of women using DMPA for up to 2 years were cultured. Mucosal immune cell populations were measured by immunohistological staining.
Results. Over 12 months, the proportion with H2O2-positive lactobacilli decreased (n = 32; 53% vs 27%; P = .03). Median vaginal CD3+ cells also decreased (n = 15; 355 vs 237 cells/mm2; P = .03), as did CD3+CCR5+ cells (195 vs 128 cells/mm2; P = .04), HLA-DR+ cells (130 vs 96 cells/mm2; P = .27), and HLA-DR+CCR5+ cells (18 vs 10 cells/mm2; P = .33).
Conclusions. DMPA contraception does not increase vaginal mucosal CCR5+ HIV target cells but does decrease CD3+ T lymphocytes and vaginal H2O2 …
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CM Mitchell, L McLemore, K Westerberg, R Astronomo… - The Journal of infectious diseases, 2014