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Medicinal plants have played a key role in world health. Plants and their products have been used since time immemorial as principal ingredients of various traditional medicines. It has been the mainstay of many traditional cultures for their low cost and wide accessibility in addition to their preventive and therapeutic value. The aim of this research was to evaluate the antioxidant and antibacterial activity of T. catappa methanolic leaf extract and its fractions. The antioxidant activity was determined using DPPH radical scavenging activity using varied concentrations (31.25-500µg/ml) of different extracts and fractions then 100µl of purified water at absorbance of 515nm using ELISA plate reader. Ascorbic acid was used as a standard. The antibacterial activity was evaluated by determining the MIC and MBC of different fractions at different concentration. The results of the study indicated the presence of major phyto-compounds like alkaloids, steroids, phenolics and saponins. It also showed that the ethyl acetate and n-butanol fractions of the leaf of T. Catappa possess the highest significant scavenging activity against DPPH•(64.02% at 250μg/ml and 62.43% at 500 μg/ml respectively). Moreover, total phenolics concentration equivalent to gallic acid was found to be up to 70 mg/g for the ethyl acetate fraction, which correlated with antioxidant activity. The result of the antibacterial study showed evidence that, the methanol leaf extract of T. Catappa possess antibacterial activity and N. butanol portion has the highest activity. In conclusion this study showed that the methanol extract and fractions of the leaf of T. Catappa have demonstrated significant …