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Cassia singueana, a medium-sized tree which is well distributed in Benin Republic, Cameroon, Chad, Gambia, and Nigeria, is reported to have wide ethnomedicinal applications notably in fever, abdominal pain, hernia, heartburn constipation, and snakebite. This study evaluated the antischizophrenic and central nervous system depressant effect of its methanol leaf extract in mice and rats using apomorphine-induced stereotypic climbing, catalepsy test, hole-board test, beam walking assay of motor coordination deficit, and diazepam-induced sleep. Preliminary phytochemical screening revealed the presence of carbohydrate, saponins, cardiac glycoside, tannins, alkaloids, phenols, steroids, anthraquinones, and proteins. The oral median lethal dose 50% of methanol leaf extract of C. singueana was found to be 2154 mg/kg. The methanol leaf extract of C. singueana significantly (P< 0.05) and dose dependently (200, 400, and 800 mg/kg) decreased the onset and increased the duration of diazepam-induced sleep in mice. The extract also causes significant (P< 0.05) decrease in a number of head dip of mice in hole-board test.