作者
Maaike Buskermolen, Dayna R Cenin, Lise M Helsingen, Gordon Guyatt, Per Olav Vandvik, Ulrike Haug, Michael Bretthauer, Iris Lansdorp-Vogelaar
发表日期
2019/10/2
期刊
Bmj
卷号
367
出版商
British Medical Journal Publishing Group
简介
Objective
To estimate benefits and harms of different colorectal cancer screening strategies, stratified by (baseline) 15-year colorectal cancer risk.
Design
Microsimulation modelling study using MIcrosimulation SCreening ANalysis-Colon (MISCAN-Colon).
Setting
A parallel guideline committee (BMJ Rapid Recommendations) defined the time frame and screening interventions, including selection of outcome measures.
Population
Norwegian men and women aged 50-79 years with varying 15-year colorectal cancer risk (1-7%).
Comparisons
Four screening strategies were compared with no screening: biennial or annual faecal immunochemical test (FIT) or single sigmoidoscopy or colonoscopy at 100% adherence.
Main outcome measures
Colorectal cancer mortality and incidence, burdens, and harms over 15 years of follow-up. The certainty of the evidence was assessed using the GRADE approach.
Results
Over 15 …
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M Buskermolen, DR Cenin, LM Helsingen, G Guyatt… - Bmj, 2019