作者
Joly HL Kwek, Robbert De Iongh, Matthew R Digby, Marilyn B Renfree, Kevin R Nicholas, Mary Familari
发表日期
2009/5/1
期刊
Mechanisms of Development
卷号
126
期号
5-6
页码范围
449-463
出版商
Elsevier
简介
There are two phases of fore-stomach development during the first 200days of pouch life in tammar wallaby. For the first 170days, the mucosa displays an immature gastric glandular phenotype that changes to a cardia glandular phenotype, which remains for the rest of the animal’s life. During this 200-day period after birth, the pouch young (PY) is dependent on maternal milk, which progressively changes in composition. We showed previously that PY cross-fostered to host mothers at a later stage of lactation accelerated development. In this study, we investigated whether cross-fostering and exposure to late lactation stage milk affected the transition to cardia glandular phenotype. In fostered PY fore-stomach, there was increased apoptosis, but no change in cell proliferation. The parietal cell population was significantly reduced, and expression of gastric glandular phenotype marker genes (ATP4A, GKN2, GHRL …
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