作者
Mark A Espeland, Stephen R Rapp, JoAnn E Manson, Joseph S Goveas, Sally A Shumaker, Kathleen M Hayden, Julie C Weitlauf, Sarah A Gaussoin, Laura D Baker, Claudia B Padula, Lifang Hou, Susan M Resnick, WHIMSY and WHIMS-ECHO Study Groups
发表日期
2017/6/1
期刊
Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences
卷号
72
期号
6
页码范围
838-845
出版商
Oxford University Press
简介
Background
Postmenopausal hormone therapy may have long-term effects on cognitive function depending on women’s age.
Methods
Postintervention follow-up was conducted with annual cognitive assessments of two randomized controlled clinical trial cohorts, beginning an average of 6–7 years after study medications were terminated: 1,376 women who had enrolled in the Women’s Health Initiative when aged 50–54 years and 2,880 who had enrolled when aged 65–79 years. Women had been randomly assigned to 0.625mg/d conjugated equine estrogens (CEE) for those with prior hysterectomy (mean 7.1 years), CEE with 2.5mg/d medroxyprogesterone acetate for those without prior hysterectomy (mean 5.4 years), or matching placebos.
Results
Hormone therapy, when prescribed to women aged 50–54 years, had no significant long-term …
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MA Espeland, SR Rapp, JAE Manson, JS Goveas… - Journals of Gerontology Series A: Biomedical Sciences …, 2017