作者
Kathleen M Hayden, Daniel P Beavers, Susan E Steck, James R Hebert, Fred K Tabung, Nitin Shivappa, Ramon Casanova, JoAnn E Manson, Claudia B Padula, Elena Salmoirago-Blotcher, Linda G Snetselaar, Oleg Zaslavsky, Stephen R Rapp
发表日期
2017/11/1
期刊
Alzheimer's & dementia
卷号
13
期号
11
页码范围
1187-1196
出版商
No longer published by Elsevier
简介
Introduction
The Mediterranean and Dietary Approaches to Stop Hypertension diets have been associated with lower dementia risk. We evaluated dietary inflammatory potential in relation to mild cognitive impairment (MCI)/dementia risk.
Methods
Baseline food frequency questionnaires from n = 7085 women (aged 65–79 years) were used to calculate Dietary Inflammatory Index (DII) scores that were categorized into four groups. Cognitive function was evaluated annually, and MCI and all-cause dementia cases were adjudicated centrally. Mixed effect models evaluated cognitive decline on over time; Cox models evaluated the risk of MCI or dementia across DII groups.
Results
Over an average of 9.7 years, there were 1081 incident cases of cognitive impairment. Higher DII scores were associated with greater cognitive decline and earlier onset of cognitive impairment. Adjusted hazard ratios (HRs) comparing lower …
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KM Hayden, DP Beavers, SE Steck, JR Hebert… - Alzheimer's & dementia, 2017