作者
Ferdinand Köckerling, Marc A Reymond, Annelore Altendorf-Hofmann, Oho Dworak, Werner Hohenberger
发表日期
1998/1
期刊
Journal of Clinical Oncology
卷号
16
期号
1
页码范围
324-329
简介
PURPOSE
Total mesorectal excision (TME) and other technical surgical factors reduce local recurrence rate in rectal cancer. Scientific evidence of the positive effect of optimal surgery on survival is locking. Whether a reduction in the incidence of distant metastases can be achieved with optimal surgery is uncertain. We examine the effects of the quality of surgery, as reflected by local recurrence rate, on survival and the incidence of initial distant metastases.
PATIENTS AND METHODS
Between 1974 and 1991, 1,581 consecutive patients who underwent curative resection (RO) for rectal carcinoma were monitored for recurrence and survival. TME was introduced in 1985. No patient received adjuvant radiotherapy or chemotherapy. The median follow-up time was greater than 13 years.
RESULTS
The local recurrence rate decreased from 39.4% to 9.8% during the study period (P < .0001). The observed 5-year survival …
引用总数
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