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The development of biocompatible three-dimensional scaffolds that enable cellular encapsulation and cell growth is of critical importance in the emerging fields of tissue engineering and regenerative medicine. Most currently available scaffolds that have shown promise are composed of either nonbioactive polymers or naturally derived biopolymers.[1] Covalently cross-linked polymers based on polyethylene oxide (PEO), poly (l-lactide)(PLLA), and poly (lactide-coglycolic acid)(PLGA) have also received attention for use in tissue engineering as a result of their biocompatibility and biodegradability.[2] Peptide-based materials that mimic aspects of the three-dimensional matrix of cells have emerged as promising alternative designs, such as self-assembling peptide amphiphiles,[3] α helices,[4] β sheets,[5] and β-amino acid helices.[6]

We report herein on the design of a metal-triggered, selfassembling collagen peptide …