作者
Roy Issac, Jean Chmielewski
发表日期
2002/6/19
期刊
Journal of the American Chemical Society
卷号
124
期号
24
页码范围
6808-6809
出版商
American Chemical Society
简介
Self-replicating peptide systems hold great promise for a wide range of technological applications, as well as to address fundamental questions pertaining to the molecular origins of life. The development of self-replicating compounds capable of high efficiency, however, has remained elusive. Here we disclose a successful strategy whereby modulation of coiled-coil stability results in remarkable catalytic efficiency for self-replication. By shortening the peptide to the minimum length necessary for coiled-coil formation a highly efficient self-replicating system was obtained due to very low background reaction rates, bringing the efficiency close to naturally occurring enzymes.
引用总数
学术搜索中的文章
R Issac, J Chmielewski - Journal of the American Chemical Society, 2002