作者
Dwight J Rouse, Deborah G Hirtz, Elizabeth Thom, Michael W Varner, Catherine Y Spong, Brian M Mercer, Jay D Iams, Ronald J Wapner, Yoram Sorokin, James M Alexander, Margaret Harper, John M Thorp Jr, Susan M Ramin, Fergal D Malone, Marshall Carpenter, Menachem Miodovnik, Atef Moawad, Mary J O'Sullivan, Alan M Peaceman, Gary DV Hankins, Oded Langer, Steve N Caritis, James M Roberts
发表日期
2008/8/28
期刊
New England Journal of Medicine
卷号
359
期号
9
页码范围
895-905
出版商
Massachusetts Medical Society
简介
Background
Research suggests that fetal exposure to magnesium sulfate before preterm birth might reduce the risk of cerebral palsy.
Methods
In this multicenter, placebo-controlled, double-blind trial, we randomly assigned women at imminent risk for delivery between 24 and 31 weeks of gestation to receive magnesium sulfate, administered intravenously as a 6-g bolus followed by a constant infusion of 2 g per hour, or matching placebo. The primary outcome was the composite of stillbirth or infant death by 1 year of corrected age or moderate or severe cerebral palsy at or beyond 2 years of corrected age.
Results
A total of 2241 women underwent randomization. The baseline characteristics were similar in the two groups. Follow-up was achieved for 95.6% of the children. The rate of the primary outcome was not significantly different in the magnesium sulfate group and the placebo group (11.3% and 11.7 …
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