作者
Ronald J Wapner, Yoram Sorokin, Elizabeth A Thom, Francee Johnson, Donald J Dudley, Catherine Y Spong, Alan M Peaceman, Kenneth J Leveno, Margaret Harper, Steve N Caritis, Menachem Miodovnik, Brian Mercer, John M Thorp, Atef Moawad, Mary Jo O'Sullivan, Susan Ramin, Marshall W Carpenter, Dwight J Rouse, Baha Sibai, Steven G Gabbe
发表日期
2006/9/1
期刊
American journal of obstetrics and gynecology
卷号
195
期号
3
页码范围
633-642
出版商
Mosby
简介
OBJECTIVE
The purpose of this study was to determine if weekly corticosteroids improve neonatal outcome without undue harm.
STUDY DESIGN
Women 23 to 32 weeks receiving 1 course of corticosteroids 7 to 10 days prior were randomized to weekly betamethasone or placebo.
RESULTS
The study was terminated by the independent data and safety monitoring committee with 495 of the anticipated 2400 patients enrolled. There was no significant reduction in the composite primary morbidity outcome (8.0% vs 9.1%, P = .67). Repeated courses significantly reduced neonatal surfactant administration (P = .02), mechanical ventilation (P = .004), CPAP (P = .05), pneumothoraces (P = .03). There was no significant difference in mean birth weight or head circumference. The repeat group had a reduction in multiples of the birth weight median by gestational age (0.88 vs 0.91) (P = .01) and more neonates weighing less …
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RJ Wapner, Y Sorokin, EA Thom, F Johnson… - American journal of obstetrics and gynecology, 2006