作者
Mark B Landon, Catherine Y Spong, Elizabeth Thom, Marshall W Carpenter, Susan M Ramin, Brian Casey, Ronald J Wapner, Michael W Varner, Dwight J Rouse, John M Thorp Jr, Anthony Sciscione, Patrick Catalano, Margaret Harper, George Saade, Kristine Y Lain, Yoram Sorokin, Alan M Peaceman, Jorge E Tolosa, Garland B Anderson
发表日期
2009/10/1
期刊
New England Journal of Medicine
卷号
361
期号
14
页码范围
1339-1348
出版商
Massachusetts Medical Society
简介
Background
It is uncertain whether treatment of mild gestational diabetes mellitus improves pregnancy outcomes.
Methods
Women who were in the 24th to 31st week of gestation and who met the criteria for mild gestational diabetes mellitus (i.e., an abnormal result on an oral glucose-tolerance test but a fasting glucose level below 95 mg per deciliter [5.3 mmol per liter]) were randomly assigned to usual prenatal care (control group) or dietary intervention, self-monitoring of blood glucose, and insulin therapy, if necessary (treatment group). The primary outcome was a composite of stillbirth or perinatal death and neonatal complications, including hyperbilirubinemia, hypoglycemia, hyperinsulinemia, and birth trauma.
Results
A total of 958 women were randomly assigned to a study group — 485 to the treatment group and 473 to the control group. We observed no significant difference between groups in the …
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MB Landon, CY Spong, E Thom, MW Carpenter… - New England Journal of Medicine, 2009