作者
Theo Crosson, Jo-Chiao Wang, Benjamin Doyle, Hannah Merrison, Mohammad Balood, Alexandre Parrin, Maud Pascal, Barbara C Mindt, Corey R Seehus, Alp Ozcan, Xuan Huang, Elise Semenara, Nicole YY Lai, Abdelilah Majdoubi, Raja-Elie E Abdulnour, Trevor Rajchgot, Moutih Rafei, Simmie L Foster, Jacques Thibodeau, Jörg H Fritz, Bruce D Levy, Clifford J Woolf, Sebastien Talbot
发表日期
2021/6/1
期刊
Journal of Allergy and Clinical Immunology
卷号
147
期号
6
页码范围
2330-2342
出版商
Mosby
简介
Background
Lung nociceptor neurons amplify immune cell activity and mucus metaplasia in response to an inhaled allergen challenge in sensitized mice.
Objective
We sought to identify the cellular mechanisms by which these sensory neurons are activated subsequent to allergen exposure.
Methods
We used calcium microscopy and electrophysiologic recording to assess whether vagal neurons directly respond to the model allergen ovalbumin (OVA). Next, we generated the first nociceptor-specific FcεR1γ knockdown (TRPV1Cre::FcεR1γfl/fl) mice to assess whether this targeted invalidation would affect the severity of allergic inflammation in response to allergen challenges.
Results
Lung-innervating jugular nodose complex ganglion neurons express the high-affinity IgE receptor FcεR1, the levels of which increase in OVA-sensitized mice. FcεR1γ-expressing vagal nociceptor neurons respond directly to OVA …
学术搜索中的文章
T Crosson, JC Wang, B Doyle, H Merrison, M Balood… - Journal of Allergy and Clinical Immunology, 2021