作者
Perminder S Sachdev, Darren M Lipnicki, Nicole A Kochan, John D Crawford, Anbupalam Thalamuthu, Gavin Andrews, Carol Brayne, Fiona E Matthews, Blossom CM Stephan, Richard B Lipton, Mindy J Katz, Karen Ritchie, Isabelle Carrière, Marie-Laure Ancelin, Linda CW Lam, Candy HY Wong, Ada WT Fung, Antonio Guaita, Roberta Vaccaro, Annalisa Davin, Mary Ganguli, Hiroko Dodge, Tiffany Hughes, Kaarin J Anstey, Nicolas Cherbuin, Peter Butterworth, Tze Pin Ng, Qi Gao, Simone Reppermund, Henry Brodaty, Nicole Schupf, Jennifer Manly, Yaakov Stern, Antonio Lobo, Raúl Lopez-Anton, Javier Santabárbara, Cohort Studies of Memory in an International Consortium (COSMIC)
发表日期
2015/11/5
期刊
PloS one
卷号
10
期号
11
页码范围
e0142388
出版商
Public Library of Science
简介
Background
Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).
Methods
Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.
Results
The published range of MCI prevalence estimates was 5.0%–36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%–10.8%); Clinical Dementia Rating of 0.5 (1.8%–14.9%); Mini-Mental State Examination score of 24–27 (2.1%–20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01).
Conclusion
Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.
学术搜索中的文章
PS Sachdev, DM Lipnicki, NA Kochan, JD Crawford… - PloS one, 2015