作者
Swadhin C Jana, Mukul Girotra, Krishanu Ray
发表日期
2011/3/15
期刊
Molecular biology of the cell
卷号
22
期号
6
页码范围
769-781
出版商
American Society for Cell Biology
简介
Structurally diverse sensory cilia have evolved from primary cilia, a microtubule-based cellular extension engaged in chemical and mechanical sensing and signal integration. The diversity is often associated with functional specialization. The olfactory receptor neurons in Drosophila, for example, express three distinct bipartite cilia displaying different sets of olfactory receptors on them. Molecular description underlying their assembly and diversification is still incomplete. Here, we show that the branched and the slender olfactory cilia develop in two distinct step-wise patterns through the pupal stages before the expression of olfactory receptor genes in olfactory neurons. The process initiates with a thin procilium growth from the dendrite apex, followed by volume increment in successive stages. Mutations in the kinesin-II subunit genes either eliminate or restrict the cilia growth as well as tubulin entry into the …
学术搜索中的文章
SC Jana, M Girotra, K Ray - Molecular biology of the cell, 2011