作者
Jieyan V Chen, Ling-Rong Kao, Swadhin C Jana, Elena Sivan-Loukianova, Susana Mendonça, Oscar A Cabrera, Priyanka Singh, Clemens Cabernard, Daniel F Eberl, Monica Bettencourt-Dias, Timothy L Megraw
发表日期
2015/10/26
期刊
Journal of Cell Biology
卷号
211
期号
2
页码范围
435-453
出版商
The Rockefeller University Press
简介
Cilia are essential for cell signaling and sensory perception. In many cell types, a cytoskeletal structure called the ciliary rootlet links the cilium to the cell body. Previous studies indicated that rootlets support the long-term stability of some cilia. Here we report that Drosophila melanogaster Rootletin (Root), the sole orthologue of the mammalian paralogs Rootletin and C-Nap1, assembles into rootlets of diverse lengths among sensory neuron subtypes. Root mutant neurons lack rootlets and have dramatically impaired sensory function, resulting in behavior defects associated with mechanosensation and chemosensation. Root is required for cohesion of basal bodies, but the cilium structure appears normal in Root mutant neurons. We show, however, that normal rootlet assembly requires centrioles. The N terminus of Root contains a conserved domain and is essential for Root function in vivo. Ectopically expressed …
引用总数
201620172018201920202021202220232024498898554
学术搜索中的文章