作者
Davy Cheng, Janet Martin, Hani Shennib, Joel Dunning, Claudio Muneretto, Stephan Schueler, Ludwig Von Segesser, Paul Sergeant, Marko Turina
发表日期
2010/3/9
来源
Journal of the American College of Cardiology
卷号
55
期号
10
页码范围
986-1001
出版商
American College of Cardiology Foundation
简介
Objectives
The purpose of this study was to determine whether thoracic endovascular aortic repair (TEVAR) reduces death and morbidity compared with open surgical repair for descending thoracic aortic disease.
Background
The role of TEVAR versus open surgery remains unclear. Metaregression can be used to maximally inform adoption of new technologies by utilizing evidence from existing trials.
Methods
Data from comparative studies of TEVAR versus open repair of the descending aorta were combined through meta-analysis. Metaregression was performed to account for baseline risk factor imbalances, study design, and thoracic pathology. Due to significant heterogeneity, registry data were analyzed separately from comparative studies.
Results
Forty-two nonrandomized studies involving 5,888 patients were included (38 comparative studies, 4 registries). Patient characteristics were balanced except for age …
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