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Antithrombotics, including anticoagulants, antiplatelet agents, and thrombolytics are used to treat or decrease the risk of thrombotic or embolic events in a wide variety of medical conditions. With the introduction of new antithrombotics to the market, an aging patient population, and the increasing prevalence of atrial fibrillation, the use of antithrombotics is expected to continue to rise in future years (9, 10). As compared with patients experiencing spontaneous intracranial hemorrhage without anticoagulation, those on antithrombotics have a higher likelihood of secondary hematoma expansion and an increased risk of death or poor functional outcome (5, 11, 12). Though antithrombotic-associated intracranial hemorrhage can be devastating, rapid reversal of coagulopathy may help limit hematoma expansion and improve outcomes.