作者
Mi Kyoung Seo, Sehoon Jeong, Dae-Hyun Seog, Jung An Lee, Jae-Hon Lee, Yena Lee, Roger S McIntyre, Sung Woo Park, Jung Goo Lee
发表日期
2023/3/1
期刊
Journal of Affective Disorders
卷号
324
页码范围
8-15
出版商
Elsevier
简介
Background
We investigated the effects of liraglutide, a glucagon-like peptide-1 (GLP-1) agonist, on a depression-like phenotype in mice exposed to chronic unpredictable stress (CUS). Learning and memory were also assessed using the Morris water maze (MWM) test.
Methods
Liraglutide (0.3 mg/kg/day for 21 days) was administered to mice with or without exposure to CUS. After 21 days of CUS, the forced swim test (FST) was performed to assess its antidepressant effect. To evaluate cognitive function, liraglutide was administered to mice under stress-free conditions for 21 days, and then the MWM test was performed on 6 consecutive days.
Results
Chronic liraglutide treatment reduced FST immobility in mice with and without CUS. In the probe trial of the Morris water maze test, the search error rate was reduced and the time spent and path length in the target quadrant and the number of platform crossings were …
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MK Seo, S Jeong, DH Seog, JA Lee, JH Lee, Y Lee… - Journal of Affective Disorders, 2023