作者
Paul G Shekelle, Michael W Rich, Sally C Morton, Col Sid W Atkinson, Wenli Tu, Margaret Maglione, Shannon Rhodes, Michael Barrett, Gregg C Fonarow, Barry Greenberg, Paul A Heidenreich, Tom Knabel, Marvin A Konstam, Anthony Steimle, Lynne Warner Stevenson
发表日期
2003/5/7
期刊
Journal of the American College of Cardiology
卷号
41
期号
9
页码范围
1529-1538
出版商
American College of Cardiology Foundation
简介
Objectives
This study sought to assess the effect of angiotensin-converting enzyme (ACE) inhibitors and beta-blockers on all-cause mortality in patients with left ventricular (LV) systolic dysfunction according to gender, race, and the presence of diabetes.
Background
Major randomized clinical trials have established that ACE inhibitors and beta-blockers have life-saving benefits in patients with LV systolic dysfunction. Most patients enrolled in these trials were Caucasian men. Whether an equal effect is achieved in women, non-Caucasians, and patients with major comorbidities has not been established.
Methods
The authors performed a meta-analysis of published and individual patient data from the 12 largest randomized clinical trials of ACE inhibitors and beta-blockers to produce random effects estimates of mortality for subgroups.
Results
Data support beneficial reductions in all-cause mortality for the use of beta …
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PG Shekelle, MW Rich, SC Morton, CSW Atkinson… - Journal of the American College of Cardiology, 2003