作者
Victor D Torres Roldan, Oscar J Ponce, Meritxell Urtecho, Gabriel F Torres, Tereza Belluzzo, Victor Montori, Carolina Liu, Francisco Barrera, Alejandro Diaz, Larry Prokop, Gordon Guyatt, Victor M Montori
发表日期
2021/11/1
来源
Journal of Clinical Epidemiology
卷号
139
页码范围
160-166
出版商
Pergamon
简介
Background and Objective
Recommendations for preventing cardiovascular (CV) disease are currently separated into primary and secondary prevention. We hypothesize that relative effects of interventions for CV prevention are not different across primary and secondary prevention cohorts. Our aim was to test for differences in relative effects on CV events in common preventive CV interventions across primary and secondary prevention cohorts.
Methods and Results
A systematic search was performed to identify individual patient data (IPD) meta-analyses that included both primary and secondary prevention populations. Eligibility assessment, data extraction, and risk of bias assessment were conducted independently and in duplicate. We extracted relative risks (RR) with 95% confidence intervals (95% CI) of the interventions over patient-important outcomes and estimated the ratio of RR for primary and secondary …
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VDT Roldan, OJ Ponce, M Urtecho, GF Torres… - Journal of Clinical Epidemiology, 2021