作者
Ilya M Nasrallah, Nicholas M Pajewski, Alexander P Auchus, Gordon Chelune, Alfred K Cheung, Maryjo L Cleveland, Laura H Coker, Michael G Crowe, William C Cushman, Jeffrey A Cutler, Christos Davatzikos, Lisa Desiderio, Jimit Doshi, Guray Erus, Larry J Fine, Sarah A Gaussoin, Darrin Harris, Karen C Johnson, Paul L Kimmel, Manjula Kurella Tamura, Lenore J Launer, Alan J Lerner, Cora E Lewis, Jennifer Martindale-Adams, Claudia S Moy, Linda O Nichols, Suzanne Oparil, Paula K Ogrocki, Mahboob Rahman, Stephen R Rapp, David M Reboussin, Michael V Rocco, Bonnie C Sachs, Kaycee M Sink, Carolyn H Still, Mark A Supiano, Joni K Snyder, Virginia G Wadley, Jennifer Walker, Daniel E Weiner, Paul K Whelton, Valerie M Wilson, Nancy Woolard, Jackson T Wright, Clinton B Wright, Jeff D Williamson, R Nick Bryan, SPRINT MIND Investigators for the SPRINT Research Group
发表日期
2019/8/13
期刊
Jama
卷号
322
期号
6
页码范围
524-534
出版商
American Medical Association
简介
Importance
The effect of intensive blood pressure lowering on brain health remains uncertain.
Objective
To evaluate the association of intensive blood pressure treatment with cerebral white matter lesion and brain volumes.
Design, Setting, and Participants
A substudy of a multicenter randomized clinical trial of hypertensive adults 50 years or older without a history of diabetes or stroke at 27 sites in the United States. Randomization began on November 8, 2010. The overall trial was stopped early because of benefit for its primary outcome (a composite of cardiovascular events) and all-cause mortality on August 20, 2015. Brain magnetic resonance imaging (MRI) was performed on a subset of participants at baseline (n = 670) and at 4 years of follow-up (n = 449); final follow-up date was July 1, 2016.
Interventions
Participants were randomized to a systolic blood pressure (SBP) goal of either less than 120 mm Hg …
学术搜索中的文章
IM Nasrallah, NM Pajewski, AP Auchus, G Chelune… - Jama, 2019
