作者
Stephen R Rapp, L Doug Case, Ann Peiffer, Michelle M Naughton, Michael D Chan, Volker W Stieber, Dennis F Moore Jr, Steven C Falchuk, James V Piephoff, William J Edenfield, Jeffrey K Giguere, Monica E Loghin, Edward G Shaw
发表日期
2015/5/20
期刊
Journal of Clinical Oncology
卷号
33
期号
15
页码范围
1653-1659
出版商
American Society of Clinical Oncology
简介
Purpose
Neurotoxic effects of brain irradiation include cognitive impairment in 50% to 90% of patients. Prior studies have suggested that donepezil, a neurotransmitter modulator, may improve cognitive function.
Patients and Methods
A total of 198 adult brain tumor survivors ≥ 6 months after partial- or whole-brain irradiation were randomly assigned to receive a single daily dose (5 mg for 6 weeks, 10 mg for 18 weeks) of donepezil or placebo. A cognitive test battery assessing memory, attention, language, visuomotor, verbal fluency, and executive functions was administered before random assignment and at 12 and 24 weeks. A cognitive composite score (primary outcome) and individual cognitive domains were evaluated.
Results
Of this mostly middle-age, married, non-Hispanic white sample, 66% had primary brain tumors, 27% had brain metastases, and 8% underwent prophylactic cranial irradiation. After 24 …
学术搜索中的文章
SR Rapp, LD Case, A Peiffer, MM Naughton, MD Chan… - Journal of Clinical Oncology, 2015