作者
Susan M Resnick, Pauline M Maki, Stephen R Rapp, Mark A Espeland, Robert Brunner, Laura H Coker, Iris A Granek, Patricia Hogan, Judith K Ockene, Sally A Shumaker, Women’s Health Initiative Study of Cognitive Aging Investigators
发表日期
2006/5/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
91
期号
5
页码范围
1802-1810
出版商
Oxford University Press
简介
Context: Some studies of hormone treatment in postmenopausal women suggest benefits on specific cognitive functions, particularly memory.
Objective: The objective of this study was to determine whether hormone therapy influences changes in specific cognitive functions and affect in older women.
Design: This study was a randomized, double-blind, placebo-controlled clinical trial.
Setting: Participants were women from 14 of 40 clinical centers of the Women’s Health Initiative (WHI).
Participants: Postmenopausal women (1416) aged 65 yr and older, free of probable dementia, and enrolled in WHI and the WHI Memory Study (WHIMS) trial of combination estrogen and progestin for a mean of 3 yr and followed for a mean of 1.35 yr, were studied.
Intervention: Intervention was conjugated equine estrogen (CEE; 0.625 mg) with 2.5 mg medroxyprogesterone …
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