作者
Mercedes C Becerra, Sasha C Appleton, Molly F Franke, Katiuska Chalco, Fernando Arteaga, Jaime Bayona, Megan Murray, Sidney S Atwood, Carole D Mitnick
发表日期
2011/1/8
期刊
The Lancet
卷号
377
期号
9760
页码范围
147-152
出版商
Elsevier
简介
Background
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis have emerged as major global health threats. WHO recommends contact investigation in close contacts of patients with MDR and XDR tuberculosis. We aimed to assess the burden of tuberculosis disease in household contacts of such patients.
Methods
We undertook a retrospective cohort study of household contacts of patients treated for MDR or XDR tuberculosis in Lima, Peru, in 1996–2003. The primary outcome was active tuberculosis in household contacts at the time the index patient began MDR tuberculosis treatment and during the 4-year follow-up. We examined whether the occurrence of active tuberculosis in the household contacts differed by resistance pattern of the index patient: either MDR or XDR tuberculosis.
Findings
693 households of index patients with MDR tuberculosis were enrolled in the study. In 48 …
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