作者
Sonya S Shin, Salmaan Keshavjee, Irina Y Gelmanova, Sidney Atwood, Molly F Franke, Sergey P Mishustin, Aivar K Strelis, Yevgeny G Andreev, Alexander D Pasechnikov, Alexander Barnashov, Tamara P Tonkel, Ted Cohen
发表日期
2010/8/1
期刊
American journal of respiratory and critical care medicine
卷号
182
期号
3
页码范围
426-432
出版商
American Thoracic Society
简介
Rationale: Extensively drug-resistant (XDR) tuberculosis (TB) may arise in individuals on treatment for multidrug-resistant (MDR) TB. Preventing this amplification of resistance will likely improve clinical outcomes and delay the secondary spread of XDR-TB.
Objectives: To measure the proportion of individuals that develops XDR-TB during the course of MDR-TB treatment, and to identify those factors associated with the development of XDR.
Methods: We performed a retrospective analysis of 608 consecutive patients with documented MDR-TB who were started on MDR-TB treatment between September 10, 2000 and November 1, 2004 in the Tomsk Oblast TB Treatment Services in Western Siberia, Russian Federation.
Measurements and Main Results: A total of 6% of patients were observed to develop XDR-TB while on MDR-TB treatment. These patients were significantly less likely to be cured or to complete …
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SS Shin, S Keshavjee, IY Gelmanova, S Atwood… - American journal of respiratory and critical care …, 2010