作者
SS Shin, AD Pasechnikov, IY Gelmanova, GG Peremitin, AK Strelis, S Mishustin, A Barnashov, Y Karpeichik, YG Andreev, VT Golubchikova, TP Tonkel, GV Yanova, A Yedilbayev, ML Rich, JS Mukherjee, JJ Furin, S Atwood, PE Farmer, S Keshavjee
发表日期
2007/12/1
期刊
The International Journal of Tuberculosis and Lung Disease
卷号
11
期号
12
页码范围
1314-1320
出版商
International Union Against Tuberculosis and Lung Disease
简介
BACKGROUND AND SIGNIFICANCE
Treatment of multidrug-resistant tuberculosis (MDR-TB) is challenging because of the toxicity of second-line medications. Little is known about whether adverse events impact treatment outcome.
METHODS
We conducted a retrospective case series of 244 MDR-TB patients enrolled in Tomsk between 10 September 2000 and 10 September 2002. Adverse reactions were determined by laboratory data and/or clinical criteria. A multiple logistic regression model was performed to determine whether the occurrence of adverse reactions was associated with poor treatment outcome.
RESULTS
In this cohort, 76.0% were cured, 6.6% failed, 4.9% died and 11.5% defaulted. Adverse events were observed in 73.3% of patients, occurring in 74.8% of patients who were adherent (taking at least 80% of prescribed doses) and 59.1% of non-adherent individuals (P = 0.11). The impact of …
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