作者
S Keshavjee, IY Gelmanova, SS Shin, SP Mishustin, YG Andreev, S Atwood, JJ Furin, A Miller
发表日期
2012/5/1
期刊
The International journal of tuberculosis and lung disease
卷号
16
期号
5
页码范围
596-603
出版商
International Union Against Tuberculosis and Lung Disease
简介
SETTING
Multidrug-resistant tuberculosis (MDR-TB) treatment program in Tomsk, Russia.
OBJECTIVE
To describe the incidence and management of hepatotoxicity during treatment of MDR-TB, and to assess risk factors associated with its development and impact on treatment outcomes.
DESIGN
A retrospective case series performed among 608 patients.
RESULTS
Hepatotoxicity, using American Thoracic Society (2006) definitions, was observed in 91/568 patients (16.5%). The median time to the first hepatotoxic event was 196 days post treatment commencement. Baseline factors associated with hepatotoxicity included elevated alanine aminotransferase/aspartate aminotransferase/bilirubin (OR 53.9, 95%CI 6.30–438.7), and renal insufficiency (OR 19.6, 95%CI 2.71–141.6). High treatment adherence (OR 3.25, 95%CI 2.07–5.09) and starting treatment in prison (OR 1.77, 95%CI 1.04–3.01) were associated with …
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