作者
Tariq Ahmad, Teresa Wang, Emily C O'Brien, Marc D Samsky, John A Pura, Yuliya Lokhnygina, Joseph G Rogers, Adrian F Hernandez, Damian Craig, Dawn E Bowles, Carmelo A Milano, Svati H Shah, James L Januzzi, G Michael Felker, Chetan B Patel
发表日期
2015/1
期刊
JACC: Heart Failure
卷号
3
期号
1
页码范围
30-39
出版商
American College of Cardiology Foundation
简介
Objectives
The purpose of this study was to examine changes in a broad panel of biomarkers following left ventricular assist device (LVAD) support in advanced heart failure (HF).
Background
LVAD therapy mechanically unloads the failing heart and may result in reversal of certain aspects of the end-stage HF phenotype. Changes in markers of myocardial stress, fibrosis, inflammation, fluid homeostasis, and renal injury in this setting are unknown.
Methods
Amino-terminal pro-B-type natriuretic peptide (NT-proBNP), galectin-3, ST2, copeptin, growth differentiation factor (GDF)-15, C-reactive protein (CRP), and neutrophil gelatinase associated lipocalin (NGAL) levels were measured in frozen plasma collected from 37 individuals prior to continuous flow LVAD implantation and a median of 136 (interquartile range: 94 to 180) days after implantation.
Results
The median age of patients was 68 years old. LVAD therapy was …
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T Ahmad, T Wang, EC O'Brien, MD Samsky, JA Pura… - JACC: Heart Failure, 2015