作者
Valentina Svicher, Valeria Cento, Martina Bernassola, Maria Neumann-Fraune, Formijn Van Hemert, Mengjie Chen, Romina Salpini, Chang Liu, Roberta Longo, Michela Visca, Sara Romano, Valeria Micheli, Ada Bertoli, Caterina Gori, Francesca Ceccherini-Silberstein, Cesare Sarrecchia, Massimo Andreoni, Mario Angelico, Antonella Ursitti, Alberto Spanò, Jing Maria Zhang, Jens Verheyen, Giuseppina Cappiello, Carlo Federico Perno
发表日期
2012/1/31
期刊
Antiviral research
卷号
93
期号
1
页码范围
86-93
出版商
Elsevier
简介
Occult HBV infection (OBI) is a threat for the safety of blood-supply, and has been associated with the onset of HBV-related hepatocellular carcinoma and lymphomagenesis. Nevertheless, genetic markers in HBsAg (particularly in D-genotype, the most common in Europe) significantly associated with OBI in vivo are missing. Thus, the goal of this study is to define: (i) prevalence and clinical profile of OBI among blood-donors; (ii) HBsAg-mutations associated with OBI; (iii) their impact on HBsAg-detection. OBI was searched among 422,278 blood-donors screened by Nucleic-Acid-Testing. Following Taormina-OBI-definition, 26 (0.006%) OBI-patients were identified. Despite viremia <50IU/ml, HBsAg-sequences were obtained for 25/26 patients (24/25 genotype-D). OBI-associated mutations were identified by comparing OBI-HBsAg with that of 82 chronically-infected (genotype-D) patients as control. Twenty HBsAg …
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V Svicher, V Cento, M Bernassola, M Neumann-Fraune… - Antiviral research, 2012