作者
Roger D Pechous, Travis R McCarthy, Thomas C Zahrt
发表日期
2009/12
来源
Microbiology and molecular biology reviews
卷号
73
期号
4
页码范围
684-711
出版商
American Society for Microbiology
简介
Francisella tularensis is a facultative intracellular gram-negative pathogen and the etiological agent of the zoonotic disease tularemia. Recent advances in the field of Francisella genetics have led to a rapid increase in both the generation and subsequent characterization of mutant strains exhibiting altered growth and/or virulence characteristics within various model systems of infection. In this review, we summarize the major properties of several Francisella species, including F. tularensis and F. novicida, and provide an up-to-date synopsis of the genes necessary for pathogenesis by these organisms and the determinants that are currently being targeted for vaccine development.
学术搜索中的文章
Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development
RD Pechous, TR McCarthy, TC Zahrt - Microbiology and molecular biology reviews, 2009