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Aim

This study was designed to evaluate the efficiency of montelukast as a novel radioprotective agent against sodium [131 I] iodide or potassium [131 I] iodide (131 I)-induced salivary gland damage in a rat model.

Materials and methods

The function and structure of salivary glands in 50 albino Wistar rats were evaluated with technetium-99m pertechnetate scintigraphies and histopathological examination. The animals were classified into five groups as follows: the control group (sham operated); group 1 (n= 10; only 131 I administration), group 2 (n= 10; administration with 131 I and montelukast); group 3 (n= 10; 131 I administration after total thyroidectomy); and group 4 (n= 10; administration with 131 I and montelukast after total thyroidectomy). All rats were killed at the end of the third month and three pairs of salivary glands were removed surgically.

Results

The scintigraphic evaluation revealed better results for …