作者
Emily Bernstein, Sang Yong Kim, Michelle A Carmell, Elizabeth P Murchison, Heather Alcorn, Mamie Z Li, Alea A Mills, Stephen J Elledge, Kathryn V Anderson, Gregory J Hannon
发表日期
2003/11/1
期刊
Nature genetics
卷号
35
期号
3
页码范围
215-217
出版商
Nature Publishing Group US
简介
To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.
引用总数
学术搜索中的文章
E Bernstein, SY Kim, MA Carmell, EP Murchison… - Nature genetics, 2003