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The interplay between the microbiome and the anti-tumor T cell specific response is a rising field in cancer immunotherapy. The effect of antigen homology between commensal bacteria and neo-antigen specific responses in tumors has, in concept, a high degree of targeted application. The neo-antigen response is a tumor specific antigen rising from mutation in the tumor cells has been associated with an increased anti-tumor ability with immunotherapy. Using a model of neo-antigen specificity with Kb-SIY in B16-SIY melanoma and commensal bacteria Bifidobacterium we identified a model of antigen mimicry for neo-antigen. Commensal bacteria antigen “Kb-SVY” is not inhibited from binding into the MHC molecule and leads to stable peptide MHC interactions. T cell populations for Kb-SIY and Kb-SVY show cross-reactivity for homologous antigens. And the impact of Bifidobacterium on the developing response …