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The conventional chemotherapeutics could not be traced in vivo and provide timely feedback on the clinical effectiveness of drugs.

Methods: In this study, a tumor-penetrating peptide RGERPPR (RGE) modified, Gd-DTPA conjugated, and doxorubicin (DOX) loaded Fe 3 O 4@ SiO 2@ mSiO 2 nanoparticle drug delivery system (Fe 3 O 4@ SiO 2@ mSiO 2/DOX-(Gd-DTPA)-PEG-RGE NPs) was prepared for tumor theranostics.

Results: The Fe 3 O 4@ SiO 2@ mSiO 2/DOX-(Gd-DTPA)-PEG-RGE NPs showed a z-average hydrodynamic diameter of about 90 nm, and a pH-sensitive DOX release profile. The 3 T MRI results confirmed the relaxivity of the NPs (r 1= 6.13 mM-1 S-1, r 2= 36.89 mM-1 S-1). The in vitro cellular uptake and cytotoxicity assays on U87MG cells confirmed that the conjugation of RGERPPR played a significant role in increasing the cellular uptake and cytotoxicity of the NPs. The near-infrared …