作者
Rajni Yadav, Mehar Chand Sharma, Prit Benny Malgulwar, Pankaj Pathak, Elanthenral Sigamani, Vaishali Suri, Chitra Sarkar, Amandeep Kumar, Manmohan Singh, Bhawani Shankar Sharma, Ajay Garg, Sameer Bakhshi, Mohammed Faruq
发表日期
2014/3/1
期刊
Neuro-oncology
卷号
16
期号
3
页码范围
372-381
出版商
Oxford University Press
简介
Background
Chordomas are slow-growing tumors and most commonly involve the sacrum and clivus. Multiple recurrences are frequent. Childhood chordomas are rare and often show exceptionally aggressive behavior, resulting in short survival and a high incidence of metastatic spread.
Objective
This study examined the histologic features and immunohistochemical profile of pediatric chordomas and compared them with their adult counterparts.
Methods
Nine pediatric and 13 adult cases were included in the study. Childhood chordomas were classified into conventional, atypical, and poorly differentiated types. Immunohistochemistry was performed for cytokeratin, epithelial membrane antigen, vimentin, S100, brachyury, p53, INI1, epidermal growth factor receptor (EGFR), and CD117. Cytogenetic analyses were performed in a subset of tumors for …
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R Yadav, MC Sharma, PB Malgulwar, P Pathak… - Neuro-oncology, 2014